COX-2 correlates with VEGF and angiogenesis in hepatitis B-linked cancer.

2004 JUN 1 - (NewsRx.com & NewsRx.net) -- COX-2 correlates with VEGF and angiogenesis in hepatitis B-linked cancer.

According to a study from the Peoples Republic of China, "evidence indicates that cyclooxygenase (COX)-2-derived prostaglandins (PGs) contribute to tumor growth by inducing angiogenesis. We investigated the role of COX-2 in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). COX-2 and vascular endothelial growth factor (VEGF) expressions were examined by immunohistochemistry in 24 HBV-associated HCC.

"Tumor micro-vessel density (MVD) was assessed using CD34 immunohistochemistry. Hep3B HCC cell line, which carries integrated HBV …